Dr. Matthew Irwine earned a Bachelor of Science degree from the University of Miami. He then received a Doctor of Medicine degree from Florida State University College of Medicine. He then completed an internal medicine internship followed by a radiology residency with the Ochsner Clinic Foundation where he served as chief resident of radiology in his senior year.

Following the completion of residency, Dr. Irwine completed a musculoskeletal radiology fellowship at the University of Alabama at Birmingham. He is an active member of the American College of Radiology.